The 1925 Ole Miss Rebels football team was an American football team that represented the University of Mississippi as a member of the Southern Conference during its 1925 season. The team compiled a 5–5 record (0–4 against conference opponents), tied for last place in the conference, and outscored opponents by a total of 147 to 87. In February 1925, Homer Hazel signed to become the head football coach at Ole Miss.
Four Ole Miss players were selected by the Daily Clarion-Ledger as first-team players on its 1925 All-Mississippi football team: Mitchell Salloum at left tackle; V. K. Smith at left guard; Ap Applewhite at right end; and Sollie Cohen at fullback. Quarterback Dick Cook and left halfback Van Martin were named to the second team. Other key players included Webb Burke at center.
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